Placenta specific 8

Placenta specific 8 is a protein that in humans is encoded by the PLAC8 gene.

PLAC8
Identifiers
Aliases	PLAC8, C15, DGIC, onzin, PNAS-144, placenta specific 8, placenta associated 8
External IDs	OMIM: 607515; MGI: 2445289; HomoloGene: 32328; GeneCards: PLAC8; OMA:PLAC8 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.22 Start 83,090,048 bp End 83,137,075 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E4|5 48.49 cM Start 100,701,591 bp End 100,720,111 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of transverse colon mucosa of sigmoid colon epithelium of nasopharynx bone marrow granulocyte mucosa of ileum trabecular bone bone marrow cells rectum Top expressed in gastrula duodenum mucous cell of stomach jejunum colon left colon pyloric antrum decidua tibiofemoral joint ileum More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding Cellular component extracellular region azurophil granule lumen Biological process positive regulation of cell population proliferation response to cold negative regulation of multicellular organism growth defense response to bacterium negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II brown fat cell differentiation neutrophil degranulation positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51316 231507 Ensembl ENSG00000145287 ENSMUSG00000029322 UniProt Q9NZF1 Q9JI48 RefSeq (mRNA) NM_016619 NM_001130715 NM_001130716 NM_139198 NM_001370754 RefSeq (protein) NP_001124187 NP_001124188 NP_057703 NP_631937 NP_001357683 Location (UCSC) Chr 4: 83.09 – 83.14 Mb Chr 5: 100.7 – 100.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ (2010). "The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation". Leukemia. 24 (3): 544–51. doi:10.1038/leu.2009.280. PMID 20072156. S2CID 205193718.
• Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT (2013). "Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types". Curr Cancer Drug Targets. 13 (1): 80–91. doi:10.2174/156800913804486584. PMID 22920440.
• Uehara H, Takahashi T, Izumi K (2013). "Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin". Int. J. Oncol. 43 (2): 365–74. doi:10.3892/ijo.2013.1954. PMC 3775580. PMID 23708710.
• Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ (2014). "Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer". J. Clin. Invest. 124 (5): 2172–87. doi:10.1172/JCI71103. PMC 4001536. PMID 24691442.
• Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H (2014). "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression". Cell Rep. 7 (4): 1143–55. doi:10.1016/j.celrep.2014.03.061. PMC 4112575. PMID 24794439.
• Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, Gohn CR, Varberg KM, McClintick JN, Haneline LS (2015). "Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus". Diabetes. 64 (7): 2664–75. doi:10.2337/db14-1709. PMC 4477353. PMID 25720387.
• Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M (2016). "PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways". Cancer Res. 76 (1): 96–107. doi:10.1158/0008-5472.CAN-15-0216. PMID 26669866.
• Li M, Liu D, Wang L, Wang W, Wang A, Yao Y (2016). "Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation". Fertil. Steril. 106 (3): 781–789.e2. doi:10.1016/j.fertnstert.2016.05.018. PMID 27322877.