RUF1 is a non-coding RNA (ncRNA) present within the plasmodium genome. Bioinformatic studies predicted that RUF1 was present in the plasmodium genome and the expression of this ncRNA was verified by northern blot.[1] The location of this ncRNAs was subsequently mapped within the P. falciparum strain 3DF genome by primer extension. RUF1 is a novel RNA of unknown function but has shown to contain some structural similarity with the H/ACA box snoRNA but no known targets have been identified.
| Plasmodium RNA of unknown function 1 | |
|---|---|
 Secondary structure of RUF1 | |
| Identifiers | |
| Symbol | RUF1 |
| Rfam | RF01578 |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Plasmodium |
| PDB structures | PDBe |
References
edit- ^ Chakrabarti K, Pearson M, Grate L, Sterne-Weiler T, Deans J, Donohue JP, Ares M (November 2007). "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis" (Free full text). RNA. 13 (11): 1923–1939. doi:10.1261/rna.751807. PMC 2040097. PMID 17901154. Archived from the original on 2023-02-10. Retrieved 2015-08-28.