Plasmodium RUF3 RNA

RUF3 is a non-coding RNA(ncRNA) present within the plasmodium genome. Bioinformatic studies predicted that RUF3 was present within the plasmodium genome and the expression of this ncRNA was verified by Northern Blot.^[1] The location of this ncRNAs was subsequently mapped within the P. falciparum strain 3DF genome by primer extension. RUF3 is a novel RNA of unknown function but has shown to contain some structural similarity with the H/ACA box snoRNA but no known targets have been identified.

References

^ Chakrabarti, K.; Pearson, M.; Grate, L.; Sterne-Weiler, T.; Deans, J.; Donohue, P.; Ares Jr, R. (Nov 2007). "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis" (Free full text). RNA. 13 (11): 1923–1939. doi:10.1261/rna.751807. ISSN 1355-8382. PMC 2040097. PMID 17901154.

[pmid17901154-1] Chakrabarti, K.; Pearson, M.; Grate, L.; Sterne-Weiler, T.; Deans, J.; Donohue, P.; Ares Jr, R. (Nov 2007). "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis" (Free full text). RNA. 13 (11): 1923–1939. doi:10.1261/rna.751807. ISSN 1355-8382. PMC 2040097. PMID 17901154.

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