Pleckstrin homology and rhogef domain containing g3

Pleckstrin homology and RhoGEF domain containing G3 is a protein that in humans is encoded by the PLEKHG3 gene.

PLEKHG3
Identifiers
Aliases	PLEKHG3, ARHGEF43, KIAA0599, pleckstrin homology and RhoGEF domain containing G3
External IDs	OMIM: 617940; MGI: 2388284; HomoloGene: 77478; GeneCards: PLEKHG3; OMA:PLEKHG3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q23.3 Start 64,704,102 bp End 64,750,249 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 76,577,665 bp End 76,627,262 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve popliteal artery tibial arteries right coronary artery corpus callosum granulocyte body of uterus C1 segment left uterine tube left coronary artery Top expressed in ascending aorta granulocyte zygote aortic valve primary oocyte molar secondary oocyte tail of embryo lip gastrula More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 26030 263406 Ensembl ENSG00000126822 ENSMUSG00000052609 UniProt A1L390 Q4VAC9 RefSeq (mRNA) NM_001308147 NM_015549 NM_153804 RefSeq (protein) NP_001295076 NP_722499 NP_001390126 NP_001390127 Location (UCSC) Chr 14: 64.7 – 64.75 Mb Chr 12: 76.58 – 76.63 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Pleckstrin homology domain
• RhoGEF domain

Further reading

• Griswold AJ, Ma D, Sacharow SJ, Robinson JL, Jaworski JM, Wright HH, Abramson RK, Lybaek H, Øyen N, Cuccaro ML, Gilbert JR, Pericak-Vance MA (June 2011). "A de novo 1.5 Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis". Autism Res. 4 (3): 221–7. doi:10.1002/aur.186. PMC 3110642. PMID 21360829.