Pocono 500 may refer to one of three auto races held at Pocono Raceway in Pennsylvania:
- Pocono 500 (IndyCar), an Indy car race held at Pocono Raceway from 1971 to 1989, and from 2015 to 2019
- Pocono Organics CBD 325, a NASCAR race held at Pocono Raceway from 1982 to 2020, at times a 500-mile event
- HighPoint.com 400, a NASCAR race held at the Pocono Raceway from 1974 to the present, which was once a 500-mile event