Polishchuk is a Ukrainian-language toponymic surname associated with Polissya and the Polishchuk people, who live along the Ukrainian-Belarus border. The Russian-language equivalent is Poleshchuk.
The surname may refer to:
- Anatoliy Polishchuk, Ukrainian volleyball player
- Daniel Poleshchuk (born 1996), Israeli squash player
- Fedor Polishchuk
- Dmitry Polishchuk, Russian windsurfer
- Lyubov Polishchuk
- Mikhail Polischuk
- Sofia Polishchuk
- Victor Polishchuk
- Yuliya Polishchuk