Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.[1] Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.[2][3] These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.
| polypyrimidine tract binding protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTBP1 | ||||||
| Alt. symbols | PTB | ||||||
| NCBI gene | 5725 | ||||||
| HGNC | 9583 | ||||||
| OMIM | 600693 | ||||||
| RefSeq | NM_002819 | ||||||
| UniProt | P26599 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
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| polypyrimidine tract binding protein 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTBP2 | ||||||
| NCBI gene | 58155 | ||||||
| HGNC | 17662 | ||||||
| OMIM | 608449 | ||||||
| RefSeq | NM_021190 | ||||||
| UniProt | Q9UKA9 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p21.3-22.1 | ||||||
| |||||||
See also
editReferences
edit- ^ Valcárcel J, Gebauer F (November 1997). "Post-transcriptional regulation: the dawn of PTB". Current Biology. 7 (11): R705-8. Bibcode:1997CBio....7R.705V. doi:10.1016/S0960-9822(06)00361-7. PMID 9382788. S2CID 13820693.
- ^ Zhou H, Su J, Hu X, et al. (April 2020). "Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice". Cell. 181 (3): 590–603.e16. doi:10.1016/j.cell.2020.03.024. PMID 32272060. S2CID 215514410.
- ^ Qian H, Kang X, Hu J, et al. (June 2020). "Reversing a model of Parkinson's disease with in situ converted nigral neurons". Nature. 582 (7813): 550–556. Bibcode:2020Natur.582..550Q. doi:10.1038/s41586-020-2388-4. PMC 7521455. PMID 32581380. S2CID 220051280.
External links
edit- polypyrimidine+tract-binding+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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