In neuroscience, a population spike (PS) is the shift in electrical potential as a consequence of the movement of ions involved in the generation and propagation of action potentials.[1] Population spikes often reflect synaptically induced firing and therefore, they can be classified as a type of field excitatory postsynaptic potentials.
In some areas of the brain, such as the hippocampus, neurons are arranged in such a way that they all receive synaptic inputs in the same area.[2][3] Because these neurons are in the same orientation, the extracellular signals from the generation of action potentials don't cancel out, but rather add up to give a signal that can easily be recorded with a field electrode.
The PS is usually recorded with an extracellular electrode placed close to neural cell bodies or axons.
The first interpretations of hippocampal field potentials were developed by Per Andersen.
References
edit- ^ McNaughton, B. L.; Douglas, R. M.; Goddard, G. V. (1978-11-24). "Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents". Brain Research. 157 (2): 277–293. doi:10.1016/0006-8993(78)90030-6. ISSN 0006-8993. PMID 719524. S2CID 36679732.
- ^ Krnjević, K.; Ropert, N. (1982-09-01). "Electrophysiological and pharmacological characteristics of facilitation of hippocampal population spikes by stimulation of the medial septum". Neuroscience. 7 (9): 2165–2183. doi:10.1016/0306-4522(82)90128-2. ISSN 0306-4522. PMID 6292779. S2CID 25430925.
- ^ Heginbotham, L. R.; Dunwiddie, T. V. (1991-08-01). "Long-term increases in the evoked population spike in the CA1 region of rat hippocampus induced by beta-adrenergic receptor activation". Journal of Neuroscience. 11 (8): 2519–2527. doi:10.1523/JNEUROSCI.11-08-02519.1991. ISSN 0270-6474. PMC 6575519. PMID 1678426.
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