Portal:Biography/Selected anniversaries/September 21
- 1645 – Louis Joliet, Canadian explorer (d. 1700)
- 1842 – Abdul Hamid II, Ottoman Sultan (d. 1918)
- 1866 – H. G. Wells, English writer (d. 1946)
- 1874 – Gustav Holst, English composer (d. 1934)
- 1912 – Chuck Jones, American animator (d. 2002)
- 1931 – Larry Hagman, American actor (d. 2012) (pictured)
- 1945 – Jerry Bruckheimer, American film and television producer
- 1947 – Stephen King, American author
- 1950 – Bill Murray, American actor
- 1954 – Shinzo Abe, Prime Minister of Japan (d. 2022)
- 1963 – Curtly Ambrose, West Indian cricketer
- 1968 – Ricki Lake, American actress and talk show hostess
- 1972 – Liam Gallagher, British singer (Oasis)