The known history of Puerto Rico began with the settlement of the archipelago of Puerto Rico by the Ortoiroid culture, sometime between 3000–2000 BC. Other tribes, such as the Igneri and Arawak Indians, populated the island between 120 and 1000 AD. At the time of Christopher Columbus's arrival in the New World, the dominant indigenous culture was that of the Taínos. The Taíno culture died out during the latter half of the 16th century because of exploitation, war and diseases brought by the Spanish.
Located in the northeastern Caribbean, Puerto Rico was the key to the Spanish Empire since the early years of the exploration, conquest and colonization of the New World. The smallest of the Greater Antilles, Puerto Rico was a major military post during many wars between Spain and other European powers for control of the region during the 16th, 17th and 18th centuries. The island was a stepping-stone in the passage from Europe to Cuba, Mexico, Central America, and the northern territories of South America. Throughout most of the 19th century and until the conclusion of the Spanish–American War, Puerto Rico and Cuba were the last two Spanish colonies in the New World and served as the final outposts in Spanish strategies to regain control of the American continents.