Cuba-United States relations date back long before either of their independence movements. Plans for purchase of the nearby island have been put forward at various times by the United States. As the Spanish influence waned, the United States gradually gained a position of economic and political dominance over the island, with the vast majority of foreign investment holdings, the bulk of imports and exports in its hands, and a major stake in Cuban political affairs to uphold. Following the Cuban Revolution of 1959 relations deteriorated substantially, and have since been marked by tension and confrontations.

The United States does not have formal diplomatic relations with Cuba and has maintained an embargo which makes it illegal for U.S. corporations to do business with Cuba. US diplomatic representation in Cuba is handled by the United States Interests Section in Havana and a similar "Cuban Interests Section" remains in Washington; both are officially part of the respective embassies of Switzerland.