Portal:Music/DateOfBirth/October 21
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- Manfred Mann (nee Michael Lubowitz), Brit keyboardist and singer, turns 84.
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- Steve Cropper, (a.k.a. "The Colonel") American Songwriters Hall of Fame inductee and guitarist for Booker T and the MG's, turns 83.
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- Elvin Bishop, American blues singer and guitarist, turns 82.
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- Ron Elliott (musician), American guitarist and vocalist for The Beau Brummels, turns 81.
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- Lee Loughnane, American trumpeter with Chicago , turns 78.
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- Tetsu Yamauchi, Japanese bassist for Faces and Free, turns 78.
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- Jerry Bergonzi, American tenor saxophonist, turns 77.
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- John Bundrick, American session musician (keyboardist) for Free, turns 76.
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- Ali Ryerson, American flautist, turns 72.
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- Marc Johnson (musician), American bandleader and composer, turns 71.
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- Charlotte Caffey, American singer and guitarist with The Graces and The Go-Go's, turns 71.
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- Eric Faulkner, Scottish guitarist, songwriter and singer for Bay City Rollers, turns 71.
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- Julian Cope, Brit guitarist and vocalist with The Teardrop Explodes, turns 67.
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- Attila the Stockbroker, Brit pop poet and songwriter, turns 67.
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- Steve Lukather, American guitarist for Toto, turns 67.
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- Rose McDowall, Scottish vocalist with Strawberry Switchblade, turns 65.
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- Tony Mortimer, Brit vocalist with East 17 , turns 53.
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- Keith Green (October 21, 1953 –July 28, 1982), (born Keith Gordon Green) American Gospel Music Hall of Fame inductee, would have turned 71 this year.
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- Brent Mydland (October 21, 1952 –July 26, 1990), American keyboardist, vocalist and songwriter of Grateful Dead fame, would have turned 72 this year.
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- Jimmy Beaumont (October 21, 1941 –October 7, 2017), American R&B vocalist with The Skyliners, would have turned 83 this year.
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- Don Rader (October 21, 1935 –April 18, 2023), American trumpeter, would have turned 89 this year.
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- Bobby Few (October 21, 1935–January 6, 2021), American pianist, would have turned 89 this year.
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- Don Elliott (October 21, 1926 –July 5, 1984), American mellophone virtuoso, would have turned 98 this year.
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- Chauncey Westbrook (October 21, 1921 –November 2, 2006), American guitarist, would have turned 103 this year.
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- Dizzy Gillespie (October 21, 1917 –January 6, 1993), (nee John Birks Gillespie) American jazz trumpeter, would have turned 107 this year.
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- Cosimo DiCeglie (1913 – 1980), Italian guitarist, would have turned 111.
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- Gus Clark (October 21, 1913 –April 19, 1979), Belgian pianist, would have turned 111 this year.
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- Don Byas (October 21, 1912 –August 24, 1972), (born Carlos Wesley Byas) American tenor saxophonist, would have turned 112 this year.