White Deer Hole Creek is a 20.5-mile (33.0 km) long tributary of the West Branch Susquehanna River in Clinton, Lycoming and Union counties in the U.S. state of Pennsylvania. A part of the Chesapeake Bay drainage basin, the White Deer Hole Creek watershed drains parts of ten townships. The creek flows east in a valley of the Ridge-and-valley Appalachians, through sandstone, limestone, and shale from the Ordovician, Silurian, and Devonian periods.
As of 2006, the creek and its 67.2 square miles (174.0 km2) watershed are relatively undeveloped, with 28.4% of the watershed given to agriculture and 71.6% covered by forest, including part of Tiadaghton State Forest. The western part of White Deer Hole Creek has very high water quality and is the only major creek in Lycoming County classified as "Class A Wild Trout Waters", defined by the Pennsylvania Fish and Boat Commission as "streams which support a population of naturally produced trout of sufficient size and abundance to support a long-term and rewarding sport fishery." The rest of the creek and its major tributary (Spring Creek) are kept stocked. There are opportunities in the watershed for canoeing, hunting, and camping, and trails for hiking and horseback riding.
Historically, two paths of the native indigenous peoples ran along parts of White Deer Hole Creek. Settlers arrived by 1770, but fled in 1778 during the American Revolutionary War. They returned and the creek served as the southern boundary of Lycoming County when it was formed in 1795. A logging railroad ran along the creek from 1901 to 1904 for timber clearcutting and small-scale lumbering continues. During World War II a TNT plant was built in the watershed, which became a federal prison in 1952. Most development is in the eastern end of the valley, with two unincorporated villages, the hamlet, and most of the farms (many Amish).