- October 22: After a poor start of the NHL season, Philadelphia Flyers general manager Bob Clarke resigns and head coach Ken Hitchcock is fired. (WCAU)
- October 20: Christoph Eschenbach announces that he will step down as the Philadelphia Orchestra's music director at the end of the 2007 - 2008 season. (Philadelphia Inquirer)
- October 16: The home of the daughter and friend of seventh district representative, Curt Weldon, is raided by the FBI in a corruption probe. (CNN)
- October 15: The Reading Terminal Market opens on Sunday for the first time. (Philadelphia Inquirer)
- October 12: Johnny Callison, former Philadelphia Phillies player, dies. (Sports Illustrated)
- October 11: Former Philadelphia Phillies player, Cory Lidle, dies in a plane crash in New York City. (CNN)
- October 6: The Philadelphia Zoo announces that its elephant habitat will be closed in 2007. (Philadelphia Inquirer)
- October 2: Four children injured at the Amish school shooting in Nickel Mines, Pennsylvania are brought to the Children's Hospital of Philadelphia. (KYW-TV)
