- October 26: Prominent judge and Philadelphia native, Lisa Richette, dies in South Philadelphia. (Philadelphia Inquirer)
- October 23: WYSP drops talk radio show Opie and Anthony. (Daily News)
- October 21: The new home of the Philadelphia Theatre Company, the Suzanne Roberts Theatre, opens along the Avenue of the Arts. (KYW-TV)
- October 18: Philadelphia city government announces that the Cradle of Liberty Council will have to pay a rent of $200,000, starting on May 31, 2008, or vacate their building. (AP)
- October 18: The owners of the boxing venue The Blue Horizon confirm that the building is up for sale. (Philadelphia Inquirer)
- October 4: Mustafa Ali is charged with the murder of two armored-truck guards in Northeast Philadelphia. (Philadelphia Inquirer)
