Sertraline (trade names Zoloft, Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in both adults and children. In 2011, it was the second-most prescribed antidepressant on the U.S. retail market, with 37 million prescriptions.
Differences with other newer antidepressants are subtle and mostly confined to side effects. Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression. Treatment of panic disorder with sertraline results in a decrease of the number of panic attacks and an improved quality of life. For obsessive-compulsive disorder, sertraline is not as effective as cognitive behavioral therapy (CBT); the best results have been achieved by combining CBT with an SSRI. Sertraline is also effective for the treatment of social phobia and posttraumatic stress disorder. (Full article...)