Part of the original A500 near Audley.

The A500 is a major primary A road in Staffordshire and Cheshire, England. It is dual carriageway for most of its length and connects Nantwich, junctions 16 and 15 of the M6 motorway with the city of Stoke-on-Trent. Because of its shape between the motorway junctions, it is known locally as the D-Road (D is also the Roman numeral representing the number 500). In 2004 the road was stated as carrying 60,000 vehicles a day through Stoke.

It was built to provide links between Stoke-on-Trent and the M6, before being extended to Nantwich. Construction has taken place over several stages, beginning in 1962, with the final section of the original route being completed similar to the original plans in 2006. As a trunk road it is maintained by the Highways Agency.