Presilphiperfolanol synthase (EC 4.2.3.74, BcBOT2, CND15) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8β-ol-forming).[1][2] This enzyme catalyses the following chemical reaction
| Presilphiperfolanol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.74 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnesyl diphosphate + H2O presilphiperfolan-8β-ol + diphosphate
This enzyme requires Mg2+.
References
edit- ^ Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pêcheur P, Morgant G, Collado IG, Cane DE, Viaud M (2008). "Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea". ACS Chem. Biol. 3 (12): 791–801. doi:10.1021/cb800225v. PMC 2707148. PMID 19035644.
- ^ Wang CM, Hopson R, Lin X, Cane DE (2009). "Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8β-ol". J. Am. Chem. Soc. 131 (24): 8360–1. doi:10.1021/ja9021649. PMC 2702122. PMID 19476353.
External links
edit- Presilphiperfolanol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
