Prince of Wales Island may refer to:
- Australia
- Prince of Wales Island (Queensland) one of the Torres Strait Islands in Queensland, Australia
- Canada
- Prince of Wales Island, Nunavut, Arctic Archipelago
- Prince of Wales Island, Lake Nipigon, Ontario
- Malaysia
- Penang Island, Malaysia, formerly Prince of Wales Island
- USA
- Prince of Wales Island (Alaska), USA
- Prince of Wales Island, Jamaica Bay, New York