Princess Margaret Hospital may refer to:
- Princess Margaret Cancer Centre, Toronto, Canada
- Princess Margaret Hospital (Hong Kong), a major acute general hospital in Kwai Chung, Hong Kong
- Princess Margaret Hospital, Christchurch
- Princess Margaret Hospital for Children, Perth, Australia
- Princess Margaret Hospital (Roseau), Roseau, Dominica
- Princess Margaret Hospital, Funafuti, Funafuti atoll, Tuvalu
- Princess Margaret Hospital, Nassau, Bahamas
- Princess Margaret Hospital, Windsor, UK
- Princess Margaret Hospital, St. Thomas Parish, Jamaica