Pristinamycin IA (Mikamycin B) is an antibiotic cyclic peptide. It is a member of the streptogramin B group of antibiotics and one component of pristinamycin (the other being pristinamycin IIA).[1]

Pristinamycin IA
Names
Other names
Mikamycin B; Mikamycin IA; NSC 92554; PA 114B; Pristinamycin P 1; Streptogramin B; Vernamycin B
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)/t26-,31-,32+,33+,34+,36+,37+/m1/s1 ☒N
    Key: YGXCETJZBDTKRY-DZCVGBHJSA-N ☒N
  • InChI=1/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)/t26-,31-,32+,33+,34+,36+,37+/m1/s1
    Key: YGXCETJZBDTKRY-DZCVGBHJBI
  • CC[C@@H]1C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)N3CCC(=O)C[C@H]3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=C(C=C6)N(C)C)C
Properties
C45H54N8O10
Molar mass 866.96 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Notes

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  1. ^ Mayers, Douglas (2009). Antimicrobial Drug Resistance: Mechanisms of Drug Resistance. Springer Science & Business Media. p. 241. ISBN 978-1-59745-180-2.