Proline rich 11

Proline rich 11 is a protein that in humans is encoded by the PRR11 gene.

PRR11
Identifiers
Aliases	PRR11, proline rich 11
External IDs	OMIM: 615920; MGI: 2444496; HomoloGene: 10123; GeneCards: PRR11; OMA:PRR11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q22 Start 59,155,732 bp End 59,206,709 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 86,979,979 bp End 86,999,534 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell renal medulla cardia pylorus nipple superior surface of tongue ventral tegmental area buccal mucosa cell trigeminal ganglion inferior ganglion of vagus nerve Top expressed in tail of embryo genital tubercle ventricular zone hand epiblast cumulus cell granulocyte primitive streak morula thymus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55771 270906 Ensembl ENSG00000068489 ENSMUSG00000020493 UniProt Q96HE9 Q8BHE0 RefSeq (mRNA) NM_018304 NM_175563 RefSeq (protein) NP_060774 NP_060774.2 NP_780772 Location (UCSC) Chr 17: 59.16 – 59.21 Mb Chr 11: 86.98 – 87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
• Ji Y, Xie M, Lan H, Zhang Y, Long Y, Weng H, Li D, Cai W, Zhu H, Niu Y, Yang Z, Zhang C, Song F, Bu Y (2013). "PRR11 is a novel gene implicated in cell cycle progression and lung cancer". Int. J. Biochem. Cell Biol. 45 (3): 645–56. doi:10.1016/j.biocel.2012.12.002. PMID 23246489.
• Zhang C, Zhang Y, Li Y, Zhu H, Wang Y, Cai W, Zhu J, Ozaki T, Bu Y (2015). "PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC)". Biochem. Biophys. Res. Commun. 458 (3): 501–8. doi:10.1016/j.bbrc.2015.01.139. PMID 25666944.
• Zhou F, Liu H, Zhang X, Shen Y, Zheng D, Zhang A, Lai Y, Li H (2014). "Proline-rich protein 11 regulates epithelial-to-mesenchymal transition to promote breast cancer cell invasion". Int J Clin Exp Pathol. 7 (12): 8692–9. PMC 4314043. PMID 25674234.
• Chen Y, Cha Z, Fang W, Qian B, Yu W, Li W, Yu G, Gao Y (2015). "The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma". Oncotarget. 6 (24): 20419–33. doi:10.18632/oncotarget.3983. PMC 4653015. PMID 25971332.
• Zhao Q (2015). "RNAi-mediated silencing of praline-rich gene causes growth reduction in human lung cancer cells". Int J Clin Exp Pathol. 8 (2): 1760–7. PMC 4396257. PMID 25973065.
• Wang Y, Zhang Y, Zhang C, Weng H, Li Y, Cai W, Xie M, Long Y, Ai Q, Liu Z, Du G, Wang S, Niu Y, Song F, Ozaki T, Bu Y (2015). "The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development". Biochim. Biophys. Acta. 1849 (9): 1133–44. doi:10.1016/j.bbagrm.2015.07.002. PMID 26162986.
• Song Z, Liu W, Xiao Y, Zhang M, Luo Y, Yuan W, Xu Y, Yu G, Hu Y (2015). "PRR11 Is a Prognostic Marker and Potential Oncogene in Patients with Gastric Cancer". PLOS ONE. 10 (8): e0128943. Bibcode:2015PLoSO..1028943S. doi:10.1371/journal.pone.0128943. PMC 4529228. PMID 26252227.
• Wang Y, Weng H, Zhang Y, Long Y, Li Y, Niu Y, Song F, Bu Y (2017). "The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells". Int J Mol Sci. 18 (3): 534. doi:10.3390/ijms18030534. PMC 5372550. PMID 28257042.