Prostamide/prostaglandin F2alpha synthase (EC 1.11.1.20, prostamide/PGF synthase, prostamide F synthase, prostamide/prostaglandin F synthase, tPGF synthase) is an enzyme with systematic name thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase .[1][2] This enzyme catalyses the following chemical reaction
| Prostamide/prostaglandin F2alpha synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.11.1.20 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
This enzyme contains a thioredoxin-type disulfide as a catalytic group.
References
edit- ^ Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K (January 2008). "Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily". The Journal of Biological Chemistry. 283 (2): 792–801. doi:10.1074/jbc.M705638200. PMID 18006499.
- ^ Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A (January 2011). "Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system". Brain Research. 1367: 22–32. doi:10.1016/j.brainres.2010.10.019. PMID 20950588.
External links
edit- Prostamide/prostaglandin+F2alpha+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
