Protein-ribulosamine 3-kinase (EC 2.7.1.172, FN3KRP, FN3K-related protein, FN3K-RP, ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-ribulosyl-L-lysine 3-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction
| Protein-ribulosamine 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.172 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ATP + [protein]-N6-D-ribulosyl-L-lysine ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
This enzyme takes part in freeing proteins from ribulosamines or psicosamines.
References
edit- ^ Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E (December 2003). "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines". Diabetes. 52 (12): 2888–95. doi:10.2337/diabetes.52.12.2888. PMID 14633848.
- ^ Fortpied J, Gemayel R, Stroobant V, van Schaftingen E (June 2005). "Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme". The Biochemical Journal. 388 (Pt 3): 795–802. doi:10.1042/BJ20041976. PMC 1183458. PMID 15705060.
- ^ Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM (December 2008). "Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine". The Biochemical Journal. 416 (2): 281–8. doi:10.1042/BJ20080389. PMID 18637789.
External links
edit- Protein-ribulosamine+3-kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
