Protein AATF

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.

AATF
Identifiers
Aliases	AATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDs	OMIM: 608463; MGI: 1929608; HomoloGene: 40811; GeneCards: AATF; OMA:AATF - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 36,948,925 bp End 37,056,871 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 84,422,855 bp End 84,513,522 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte corpus callosum Achilles tendon tibial arteries blood skin of leg bone marrow body of pancreas sural nerve Top expressed in morula epiblast embryo tail of embryo genital tubercle primary oocyte yolk sac endothelial cell of lymphatic vessel spermatocyte embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding DNA-binding transcription factor activity leucine zipper domain binding protein binding tau protein binding RNA binding protein kinase binding Cellular component cytoplasm Golgi apparatus nucleus nucleolus Biological process embryonic cleavage ribosome biogenesis negative regulation of apoptotic process cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated cell adhesion negative regulation of amyloid precursor protein biosynthetic process regulation of mitotic cell cycle negative regulation of superoxide anion generation negative regulation of reactive oxygen species metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26574 56321 Ensembl ENSG00000275700 ENSG00000276072 ENSMUSG00000018697 UniProt Q9NY61 Q9JKX4 RefSeq (mRNA) NM_012138 NM_019816 RefSeq (protein) NP_036270 NP_062790 Location (UCSC) Chr 17: 36.95 – 37.06 Mb Chr 11: 84.42 – 84.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Interactions

Protein AATF has been shown to interact with:

• PAWR,
• POLR2J,
• Retinoblastoma protein, and
• Transcription factor Sp1.

Further reading

• Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters. 462 (1–2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. S2CID 6061613.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/S1535-6108(02)00182-4. PMID 12450794.
• Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.
• Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
• Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C (Dec 2003). "Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis". Molecular and Cellular Neurosciences. 24 (4): 1038–50. doi:10.1016/j.mcn.2003.08.002. hdl:2108/56917. PMID 14697667. S2CID 35111183.
• Burgdorf S, Leister P, Scheidtmann KH (Apr 2004). "TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination". The Journal of Biological Chemistry. 279 (17): 17524–34. doi:10.1074/jbc.M313703200. PMID 14761944.
• Xie J, Guo Q (Jun 2004). "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide". Neurobiology of Disease. 16 (1): 150–7. doi:10.1016/j.nbd.2004.02.003. PMID 15207272. S2CID 53204920.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Kaul D, Mehrotra A (Mar 2007). "Functional characterization of AATF transcriptome in human leukemic cells". Molecular and Cellular Biochemistry. 297 (1–2): 215–20. doi:10.1007/s11010-006-9317-1. PMID 17006618. S2CID 8612000.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• AATF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• AATF human gene location in the UCSC Genome Browser.
• AATF human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.