Protein DEPP

Protein DEPP also known as decidual protein induced by progesterone (DEPP) and fasting-induced gene protein (FIG) is a protein that in humans is encoded by the DEPP gene.

DEPP1
Identifiers
Aliases	DEPP1, DEPP, FIG, Fseg, chromosome 10 open reading frame 10, autophagy regulator, C10orf10, DEPP1 autophagy regulator
External IDs	OMIM: 611309; MGI: 1918730; HomoloGene: 48491; GeneCards: DEPP1; OMA:DEPP1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.21 Start 44,970,981 bp End 44,978,809 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 116,627,570 bp End 116,629,755 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell pericardium right lung saphenous vein gastric mucosa vena cava tibial nerve right coronary artery olfactory zone of nasal mucosa Descending thoracic aorta Top expressed in ciliary body intercostal muscle submandibular gland retinal pigment epithelium internal carotid artery left lung lobe external carotid artery Region I of hippocampus proper transitional epithelium of urinary bladder maxillary prominence More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 11067 213393 Ensembl ENSG00000165507 ENSMUSG00000048489 UniProt Q9NTK1 Q8K2F3 RefSeq (mRNA) NM_007021 NM_001166580 NM_145980 RefSeq (protein) NP_008952 NP_001160052 NP_666092 Location (UCSC) Chr 10: 44.97 – 44.98 Mb Chr 6: 116.63 – 116.63 Mb PubMed search
Wikidata
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Function

The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Shin D, Anderson DJ (2005). "Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells". Dev. Dyn. 233 (4): 1589–604. doi:10.1002/dvdy.20479. PMID 15977181. S2CID 20593942.
• Watanabe H, Nonoguchi K, Sakurai T, et al. (2005). "A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor". Mol. Hum. Reprod. 11 (7): 471–6. doi:10.1093/molehr/gah186. PMID 16123073.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.