Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene .[ 5] [ 6] [ 7]
CBY1 Identifiers Aliases CBY1 External IDs OMIM : 607757 ; MGI : 1920989 ; HomoloGene : 12514 ; GeneCards : CBY1 ; OMA :CBY1 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in oocyte secondary oocyte right uterine tube tendon of biceps brachii epithelium of bronchus bronchial epithelial cell muscle layer of sigmoid colon apex of heart ventricular zone right auricle
Top expressed in spermatocyte interventricular septum ventricular zone medial ganglionic eminence seminiferous tubule neural tube dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex granulocyte
More reference expression data
BioGPS
Wikidata
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[ 7]
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Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes" . Genome Res . 11 (5): 677–84. doi :10.1101/gr.gr-1640r . PMC 311086 PMID 11337467 . Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22" . Genome Res . 13 (1): 27–36. doi :10.1101/gr.695703 . PMC 430954 PMID 12529303 . Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature . 422 (6934): 905–9. Bibcode :2003Natur.422..905T . doi :10.1038/nature01570 . PMID 12712206 . S2CID 4418716 . Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?" . BMC Cancer . 4 : 31. doi :10.1186/1471-2407-4-31 PMC 471554 PMID 15245581 . Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 PMC 545604 PMID 15461802 . Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines" . World J. Gastroenterol . 12 (10): 1529–35. doi :10.3748/wjg.v12.i10.1529 PMC 4124284 PMID 16570344 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K (2007). "Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling" . Mol. Cell. Biol . 27 (12): 4347–54. doi :10.1128/MCB.01640-06 . PMC 1900052 PMID 17403895 .
