Protostadienol synthase (EC 5.4.99.32, PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction
| Protostadienol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.32 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (3S)-2,3-epoxy-2,3-dihydrosqualene (17Z)-protosta-17(20),24-dien-3beta-ol
(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.
References
edit- ^ Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP (March 2009). "Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus". Organic Letters. 11 (6): 1241–4. doi:10.1021/ol802696a. PMID 19216560.
External links
edit- Protostadienol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
