Psaila is a Maltese surname. Notable people with the surname include:
- Dun Karm Psaila (1871–1961), priest, writer and poet regarded as the "National Poet of Malta"
- Giuseppe Psaila (1891–1960), Art Nouveau architect
- Jes Psaila (born 1964), guitarist
- Natalie Psaila, Maltese doctor and abortion-rights activist
- Pippo Psaila (born 1957), football coach