Pseudaminic acid synthase

Pseudaminic acid synthase (EC 2.5.1.97, PseI, NeuB3) is an enzyme with systematic name phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transferring, 2-carboxy-2-oxoethyl-forming).[1] This enzyme catalyses the following chemical reaction

Pseudaminic acid synthase
Identifiers
EC no.2.5.1.97
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H2O 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate

The enzyme requires a divalent metal ion, preferably Mn2+ and Co2+.

References

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  1. ^ Chou WK, Dick S, Wakarchuk WW, Tanner ME (October 2005). "Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase". The Journal of Biological Chemistry. 280 (43): 35922–8. doi:10.1074/jbc.M507483200. PMID 16120604.
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