The Pseudomonas phage F116 holin is a non-characterized holin homologous to one in Neisseria gonorrheae that has been characterized.[1] This protein is the prototype of the Pseudomonas phage F116 holin (F116 Holin) family (TC# 1.E.25), which is a member of the Holin Superfamily II.[2] Bioinformatic analysis of the genome sequence of N. gonorrhoeae revealed the presence of nine probable prophage islands. The genomic sequence of FA1090 identified five genomic regions (NgoPhi1 - 5) that are related to dsDNA lysogenic phage. The DNA sequences from NgoPhi1, NgoPhi2 and NgoPhi3 contained regions of identity. A region of NgoPhi2 showed high similarity with the Pseudomonas aeruginosa generalized transducing phage F116. NgoPhi1 and NgoPhi2 encode functionally active phages. The holin gene of NgoPhi1 (identical to that encoded by NgoPhi2), when expressed in E. coli, could substitute for the phage lambda S gene.[1]
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edit- ^ a b Piekarowicz, Andrzej; Kłyz, Aneta; Majchrzak, Michał; Adamczyk-Popławska, Monika; Maugel, Timothy K.; Stein, Daniel C. (1 January 2007). "Characterization of the dsDNA prophage sequences in the genome of Neisseria gonorrhoeae and visualization of productive bacteriophage". BMC Microbiology. 7: 66. doi:10.1186/1471-2180-7-66. ISSN 1471-2180. PMC 1931599. PMID 17615066.
- ^ Reddy, Bhaskara L.; Saier, Milton H. (1 November 2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. ISSN 0006-3002. PMC 3788059. PMID 23856191.
As of 10 March 2016, this article is derived in whole or in part from Transporter Classification Database (TCDB). The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "1.E.25 The Pseudomonas phage F116 Holin (F116 Holin) Family"
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