Puff adder is the common name of several snake species:
- Bitis arietans, a venomous snake species found in Africa and the southern Arabian Peninsula
- Bitis, any other member of this genus
- Heterodon, a genus of harmless North American colubrid snakes commonly known as hognose snakes
Puff adder may also refer to:
- Puff Adder (comics), a mutant supervillain in the Marvel Universe