Pupovac (Serbian Cyrillic: Пуповац) is a Serbian surname, derived from the noun pup (bud). The surname refers to the wealthy medieval clan spreading out into a few family branches in the territory of Zadar County. It may refer to:
- Adrijana Pupovac, Serbian Politician
- Branka Pupovac, Australian Wheelchair Tennis Player
- Milorad Pupovac, Croatian-Serb Politician and Linguist
- Sergio Pupovac, French-Born Luxembourgian Footballer