The purD RNA motif is a conserved RNA structure found in Campylobacterota, such as the genera Helicobacter and Campylobacter.[1] The RNA is consistently found in the apparent 5' UTR of purD genes. purD genes encode the enzyme Phosphoribosylamine-glycine ligase, which catalyzes an early step in de novo purine synthesis. Although a possible cis-regulatory role was proposed for this motif, experimental results indicate that it overlaps the 6S RNA of the relevant species,[2] and that the second hairpin of the motif might not be biological.
| purD RNA motif | |
|---|---|
 Predicted secondary structure and sequence conservation of purD | |
| Identifiers | |
| Symbol | purD |
| Rfam | RF01069 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
References
edit- ^ Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
- ^ Sharma CM, Hoffmann S, Darfeuille F, et al. (February 2010). "The primary transcriptome of the major human pathogen Helicobacter pylori". Nature. 464 (7286): 250–255. doi:10.1038/nature08756. PMID 20164839. S2CID 205219639.
External links
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