RAB35

Ras-related protein Rab-35 is a protein that in humans is encoded by the RAB35 gene. This GTPase participates in the traffic of recycling endosomes toward the plasma membrane,

RAB35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TW8
Identifiers
Aliases	RAB35, H-ray, RAB1C, RAY, member RAS oncogene family
External IDs	OMIM: 604199; MGI: 1924657; HomoloGene: 21361; GeneCards: RAB35; OMA:RAB35 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.23 Start 120,095,099 bp End 120,117,502 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 115,769,967 bp End 115,785,795 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte stromal cell of endometrium skin of leg skin of abdomen monocyte mucosa of esophagus ganglionic eminence left uterine tube ectocervix right coronary artery Top expressed in granulocyte placenta ganglionic eminence dentate gyrus of hippocampal formation granule cell hippocampus proper primary visual cortex striatum of neuraxis lip white adipose tissue cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding phosphatidylinositol-4,5-bisphosphate binding GTPase activity Cellular component endosome membrane melanosome clathrin-coated endocytic vesicle plasma membrane mitochondrion cell projection membrane intercellular bridge clathrin-coated pit endosome membrane extracellular exosome cytoplasmic vesicle clathrin-coated vesicle cytosol clathrin-coated vesicle membrane recycling endosome membrane anchored component of synaptic vesicle membrane Golgi membrane intracellular anatomical structure Biological process protein localization cellular response to nerve growth factor stimulus antigen processing and presentation cytokinesis endosomal transport plasma membrane to endosome transport endocytic recycling protein transport protein localization to endosome neuron projection development transport mitotic cytokinesis intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11021 77407 Ensembl ENSG00000111737 ENSMUSG00000029518 UniProt Q15286 Q6PHN9 RefSeq (mRNA) NM_001167606 NM_006861 NM_198163 RefSeq (protein) NP_001161078 NP_006852 NP_937806 Location (UCSC) Chr 12: 120.1 – 120.12 Mb Chr 5: 115.77 – 115.79 Mb PubMed search
Wikidata
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Further reading

• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Kouranti I, Sachse M, Arouche N, Goud B, Echard A (Sep 2006). "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis". Current Biology. 16 (17): 1719–25. Bibcode:2006CBio...16.1719K. doi:10.1016/j.cub.2006.07.020. PMID 16950109. S2CID 17407979.
• Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications. 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.
• Zhu AX, Zhao Y, Flier JS (Dec 1994). "Molecular cloning of two small GTP-binding proteins from human skeletal muscle". Biochemical and Biophysical Research Communications. 205 (3): 1875–82. doi:10.1006/bbrc.1994.2889. PMID 7811277.