RAB3B

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.

RAB3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DZ8
Identifiers
Aliases	RAB3B, member RAS oncogene family
External IDs	OMIM: 179510; MGI: 1917158; HomoloGene: 2149; GeneCards: RAB3B; OMA:RAB3B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p32.3 Start 51,907,956 bp End 51,990,700 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C7 Start 108,736,260 bp End 108,800,521 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium beta cell gonad entorhinal cortex anterior pituitary hypothalamus superior vestibular nucleus placenta testicle Top expressed in facial motor nucleus superior frontal gyrus zygote arcuate nucleus paraventricular nucleus of hypothalamus subiculum primary visual cortex supraoptic nucleus dorsomedial hypothalamic nucleus primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding myosin V binding protein binding GTP-dependent protein binding GTPase activity Cellular component cytoplasm vesicle cytosol membrane synaptic vesicle plasma membrane secretory granule perinuclear region of cytoplasm extracellular exosome anchored component of synaptic vesicle membrane endosome Golgi apparatus dopaminergic synapse Biological process antigen processing and presentation positive regulation of dopamine uptake involved in synaptic transmission peptidyl-cysteine methylation regulation of exocytosis regulation of vesicle size protein transport transport intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane regulation of synaptic vesicle cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5865 69908 Ensembl ENSG00000169213 ENSMUSG00000003411 UniProt P20337 Q9CZT8 RefSeq (mRNA) NM_002867 NM_023537 RefSeq (protein) NP_002858 NP_076026 Location (UCSC) Chr 1: 51.91 – 51.99 Mb Chr 4: 108.74 – 108.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RAB3B has been shown to interact with RPH3A.

Further reading

• Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (February 1991). "Chromosome assignment of four RAS-related RAB genes". Human Genetics. 86 (4): 350–4. doi:10.1007/BF00201831. PMID 1999336. S2CID 30730416.
• Zahraoui A, Touchot N, Chardin P, Tavitian A (July 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.
• Weber E, Berta G, Tousson A, St John P, Green MW, Gopalokrishnan U, Jilling T, Sorscher EJ, Elton TS, Abrahamson DR (May 1994). "Expression and polarized targeting of a rab3 isoform in epithelial cells". The Journal of Cell Biology. 125 (3): 583–94. doi:10.1083/jcb.125.3.583. PMC 2119989. PMID 8175882.
• Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.
• Regazzi R, Ravazzola M, Iezzi M, Lang J, Zahraoui A, Andereggen E, Morel P, Takai Y, Wollheim CB (September 1996). "Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells". Journal of Cell Science. 109 ( Pt 9) (9): 2265–73. doi:10.1242/jcs.109.9.2265. PMID 8886977.
• Sidhu RS, Bhullar RP (December 2001). "Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin". Biochemical and Biophysical Research Communications. 289 (5): 1039–43. doi:10.1006/bbrc.2001.6113. PMID 11741295.
• van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE (February 2002). "Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells". Developmental Cell. 2 (2): 219–28. doi:10.1016/S1534-5807(02)00115-6. PMID 11832247.
• Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S, Sasaki T (August 2003). "Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane". Biochemical and Biophysical Research Communications. 308 (2): 270–5. doi:10.1016/S0006-291X(03)01358-5. PMID 12901864.
• Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.