Retinoic acid early transcript 1G (RAET1G) is a cell surface glycoprotein encoded by RAET1G gene located on chromosome 6.[1] RAET1G is related to MHC class I molecules, but its gene maps outside the MHC locus.[1] RAET1G is composed of an external α1α2 domain, a transmembrane segment, and C-terminal cytoplasmic tail.[1][2] RAET1E functions as a stress-induced ligand for NKG2D receptors.[2]
References
edit- ^ a b c Radosavljevic, Mirjana; Cuillerier, Benoı̂t; Wilson, Michael J.; Clément, Oliver; Wicker, Sophie; Gilfillan, Susan; Beck, Stephan; Trowsdale, John; Bahram, Seiamak (2002-01-01). "A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.
- ^ a b Bacon, Louise; Eagle, Robert A.; Meyer, Martina; Easom, Nicholas; Young, Neil T.; Trowsdale, John (2004-07-15). "Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D". The Journal of Immunology. 173 (2): 1078–1084. doi:10.4049/jimmunol.173.2.1078. ISSN 0022-1767. PMID 15240696.