RAPH1

Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.

RAPH1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4GMV, 4GN1
Identifiers
Aliases	RAPH1, ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
External IDs	OMIM: 609035; MGI: 1924550; HomoloGene: 71030; GeneCards: RAPH1; OMA:RAPH1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.2 Start 203,394,345 bp End 203,535,335 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 60,521,451 bp End 60,606,263 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell tibia pancreatic ductal cell endothelial cell synovial joint synovial membrane visceral pleura skin of arm cartilage tissue pars reticulata Top expressed in otolith organ utricle body of femur Rostral migratory stream myocardium of ventricle adrenal gland superior cervical ganglion substantia nigra soleus muscle left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm filopodium cell projection cytoskeleton cell leading edge membrane lamellipodium cytosol plasma membrane nuclear body Biological process signal transduction axon extension Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65059 77300 Ensembl ENSG00000173166 ENSMUSG00000026014 UniProt Q70E73 n/a RefSeq (mRNA) NM_025252 NM_203365 NM_213589 NM_001329728 NM_001045513 RefSeq (protein) NP_001316657 NP_976241 NP_998754 n/a Location (UCSC) Chr 2: 203.39 – 203.54 Mb Chr 1: 60.52 – 60.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Hadano S, Hand CK, Osuga H, et al. (2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat. Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
• Dahl E, Sadr-Nabavi A, Klopocki E, et al. (2005). "Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer". J. Pathol. 205 (1): 21–8. doi:10.1002/path.1687. PMID 15586368. S2CID 8336323.
• Eppert K, Wunder JS, Aneliunas V, et al. (2005). "Altered expression and deletion of RMO1 in osteosarcoma". Int. J. Cancer. 114 (5): 738–46. doi:10.1002/ijc.20786. PMID 15609301. S2CID 23990601.
• Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358. S2CID 25677449.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.