Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. [5]

RASGRF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
External IDsOMIM: 606600; MGI: 99694; HomoloGene: 74972; GeneCards: RASGRF1; OMA:RASGRF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145648
NM_002891
NM_153815

NM_001039655
NM_011245
NM_001357743
NM_001357744

RefSeq (protein)

NP_001139120
NP_002882
NP_722522

NP_001034744
NP_035375
NP_001344672
NP_001344673

Location (UCSC)Chr 15: 78.96 – 79.09 MbChr 9: 89.79 – 89.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058335Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032356Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ras protein-specific guanine nucleotide-releasing factor 1". Retrieved 2013-04-07.

Further reading

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