REXO4

RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.

REXO4
Identifiers
Aliases	REXO4, REX4, XPMC2, XPMC2H, REX4 homolog, 3'-5' exonuclease
External IDs	OMIM: 602930; MGI: 2684957; HomoloGene: 133948; GeneCards: REXO4; OMA:REXO4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.2 Start 133,406,059 bp End 133,418,096 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 26,843,575 bp End 26,854,398 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve skeletal muscle tissue gastrocnemius muscle muscle of thigh mucosa of transverse colon ventricular zone granulocyte ganglionic eminence apex of heart body of pancreas Top expressed in Paneth cell fossa condyle internal carotid artery external carotid artery thymus neural layer of retina motor neuron medullary collecting duct facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity nuclease activity exonuclease activity hydrolase activity nucleic acid binding RNA binding single-stranded DNA binding transcription coactivator activity endonuclease activity 3'-5' exonuclease activity Cellular component nucleolus nucleus nuclear speck Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic DNA catabolic process, exonucleolytic rRNA processing positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57109 227656 Ensembl ENSG00000280706 ENSG00000148300 ENSMUSG00000052406 UniProt Q9GZR2 Q6PAQ4 RefSeq (mRNA) NM_001279349 NM_001279350 NM_001279351 NM_020385 NM_207234 NM_001362876 RefSeq (protein) NP_001266278 NP_001266279 NP_001266280 NP_065118 NP_997117 NP_001349805 Location (UCSC) Chr 9: 133.41 – 133.42 Mb Chr 2: 26.84 – 26.85 Mb PubMed search
Wikidata
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Further reading

• Montano MM, Wittmann BM, Bianco NR (2000). "Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity". J. Biol. Chem. 275 (44): 34306–13. doi:10.1074/jbc.M003880200. PMID 10908561.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.