RGPD5

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.

RGPD5
Identifiers
Aliases	RGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDs	OMIM: 612708; MGI: 894323; HomoloGene: 87808; GeneCards: RGPD5; OMA:RGPD5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q13 Start 109,792,758 bp End 109,857,705 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 B4|10 29.34 cM Start 58,282,742 bp End 58,330,178 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon buccal mucosa cell sural nerve trachea testicle nipple pylorus muscle of thigh bone marrow cells superior surface of tongue Top expressed in human fetus Gonadal ridge lobe of cerebellum lacrimal gland cerebellar vermis spermatocyte spermatid left lung lobe primitive streak pineal gland More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component cytoplasm nucleus nuclear pore centrosome Biological process intracellular transport NLS-bearing protein import into nucleus positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84220 19386 Ensembl ENSG00000015568 ENSMUSG00000003226 UniProt Q99666 Q9ERU9 RefSeq (mRNA) NM_005054 NM_032260 NM_011240 RefSeq (protein) NP_005045 NP_115636 NP_035370 Location (UCSC) Chr 2: 109.79 – 109.86 Mb Chr 10: 58.28 – 58.33 Mb PubMed search
Wikidata
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RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.

Interactions

RGPD5 has been shown to interact with Transportin 1.

Further reading

• Cai Y, Miao SY, Wang LF (October 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 23 (5): 462–6. PMID 12905863.
• Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (January 2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Molecular Reproduction and Development. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384. S2CID 23631919.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD, Koide SS (1999). "Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene". Archives of Andrology. 42 (2): 71–84. doi:10.1080/014850199262904. PMID 10101573.
• Nothwang HG, Rensing C, Kübler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F (February 1998). "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12". Genomics. 47 (3): 383–92. doi:10.1006/geno.1997.5119. PMID 9480752.