Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.[5][6][7]

RGS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS1, 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, regulator of G protein signaling 1
External IDsOMIM: 600323; MGI: 1354694; HomoloGene: 2191; GeneCards: RGS1; OMA:RGS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002922

NM_015811

RefSeq (protein)

NP_002913

NP_056626

Location (UCSC)Chr 1: 192.58 – 192.58 MbChr 1: 144.12 – 144.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090104Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026358Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD (Jan 1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein". Biochim Biophys Acta. 1216 (2): 314–6. doi:10.1016/0167-4781(93)90163-8. PMID 8241276.
  6. ^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.
  7. ^ a b "Entrez Gene: RGS1 regulator of G-protein signalling 1".

Further reading

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