Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene .[ 5] [ 6]
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling ) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins . This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000076344 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024186 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits" . Proc Natl Acad Sci U S A . 95 (22): 13307–12. Bibcode :1998PNAS...9513307S . doi :10.1073/pnas.95.22.13307 PMC 23793 PMID 9789084 . ^ a b "Entrez Gene: RGS11 regulator of G-protein signalling 11" .
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF) . Nature . 432 (7020): 988–94. Bibcode :2004Natur.432..988M . doi :10.1038/nature03187 PMID 15616553 . S2CID 4362044 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics . 79 (2): 177–85. doi :10.1006/geno.2002.6693 . PMID 11829488 . S2CID 16065132 . Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16" . Hum. Mol. Genet . 10 (4): 339–52. doi :10.1093/hmg/10.4.339 PMID 11157797 . Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11" . Proc. Natl. Acad. Sci. U.S.A . 96 (11): 6489–94. Bibcode :1999PNAS...96.6489S . doi :10.1073/pnas.96.11.6489 PMC 26909 PMID 10339615 . Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain" . J. Neurosci . 17 (20): 8024–37. doi :10.1523/JNEUROSCI.17-20-08024.1997 . PMC 6793903 PMID 9315921 .
