RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[5] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[6][7] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[8]

RIC3
Identifiers
AliasesRIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone, RIC-3
External IDsOMIM: 610509; MGI: 2443887; HomoloGene: 49772; GeneCards: RIC3; OMA:RIC3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001038624
NM_178780
NM_001311161

RefSeq (protein)

NP_001033713
NP_001298090
NP_848895

Location (UCSC)Chr 11: 8.11 – 8.17 MbChr 7: 108.63 – 108.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166405Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048330Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics. 140 (2): 527–35. doi:10.1093/genetics/140.2.527. PMC 1206632. PMID 7498734.
  6. ^ Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem. 278 (36): 34411–7. doi:10.1074/jbc.M300170200. hdl:10261/289220. PMID 12821669.
  7. ^ "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".
  8. ^ Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

Further reading

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