Rhabdomyosarcoma 2 associated transcript (RMST) is a long non-coding RNA. In humans, it is located on chromosome 12q21. It is expressed at higher levels in alveolar rhabdomyosarcoma than in embryonal rhabdomyosarcoma.[3] In the brain, RMST is expressed in the developing ventral midbrain where dopaminergic neurons are formed, the developing isthmus and in the dorsal midline cells of the rostral neural tube.[4] In the midbrain-hindbrain boundary region, its expression is regulated by PAX2.[5]
| RMST | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RMST, LINC00054, NCRMS, NCRNA00054, rhabdomyosarcoma 2 associated transcript (non-protein coding), rhabdomyosarcoma 2 associated transcript | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607045; GeneCards: RMST; OMA:RMST - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
See also
editReferences
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000255794 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chan AS, Thorner PS, Squire JA, Zielenska M (May 2002). "Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes". Oncogene. 21 (19): 3029–3037. doi:10.1038/sj.onc.1205460. PMID 12082533.
- ^ Uhde CW, Vives J, Jaeger I, Li M (2010). "Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells". PLOS ONE. 5 (1): e8641. Bibcode:2010PLoSO...5.8641U. doi:10.1371/journal.pone.0008641. PMC 2799666. PMID 20062813.
- ^ Bouchard M, Grote D, Craven SE, Sun Q, Steinlein P, Busslinger M (June 2005). "Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region". Development. 132 (11): 2633–2643. doi:10.1242/dev.01833. PMID 15872005.
Further reading
edit- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.