E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.[5]

RNF216
Identifiers
AliasesRNF216, CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, ring finger protein 216
External IDsOMIM: 609948; MGI: 1344349; HomoloGene: 19442; GeneCards: RNF216; OMA:RNF216 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019011
NM_207111
NM_207116
NM_001377156

NM_080561
NM_207110
NM_001359851

RefSeq (protein)

NP_996994
NP_996999
NP_001364085

NP_542128
NP_996993
NP_001346780

Location (UCSC)Chr 7: 5.62 – 5.78 MbChr 5: 142.98 – 143.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.[5]

See also

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Interactions

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RNF216 has been shown to interact with TLR9[6] and RIPK1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011275Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045078Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TRIAD3 TRIAD3 protein".
  6. ^ Chuang, Tsung-Hsien; Ulevitch Richard J (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. ISSN 1529-2908. PMID 15107846. S2CID 39773935.
  7. ^ Chen, Danying; Li Xiaoyan; Zhai Zhonghe; Shu Hong-Bing (May 2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. 277 (18): 15985–91. doi:10.1074/jbc.M108675200. ISSN 0021-9258. PMID 11854271.

Further reading

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