RNF41

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

RNF41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FZP, 2GWF
Identifiers
Aliases	RNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDs	MGI: 1914838; HomoloGene: 4226; GeneCards: RNF41; OMA:RNF41 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 56,202,179 bp End 56,221,933 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 D3|10 76.55 cM Start 128,247,526 bp End 128,277,310 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 paraflocculus of cerebellum frontal pole islet of Langerhans monocyte lateral nuclear group of thalamus stromal cell of endometrium gallbladder right coronary artery popliteal artery Top expressed in seminiferous tubule dentate gyrus of hippocampal formation granule cell primary visual cortex spermatid superior frontal gyrus ventricular zone granulocyte ganglionic eminence Rostral migratory stream cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-3 receptor binding erythropoietin receptor binding zinc ion binding metal ion binding protein binding transferase activity ubiquitin-protein transferase activity protein domain specific binding receptor tyrosine kinase binding ubiquitin protein ligase activity Cellular component cytosol perinuclear region of cytoplasm endoplasmic reticulum tubular network Biological process regulation of MAPK cascade extrinsic apoptotic signaling pathway positive regulation of DNA-binding transcription factor activity protein polyubiquitination regulation of reactive oxygen species metabolic process autophagy negative regulation of cell migration regulation of lymphocyte differentiation positive regulation of reactive oxygen species metabolic process protein ubiquitination regulation of protein kinase B signaling regulation of gene expression proteasomal protein catabolic process regulation of myeloid cell differentiation regulation of establishment of cell polarity negative regulation of cell population proliferation protein autoubiquitination apoptotic process negative regulation of mitophagy positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10193 67588 Ensembl ENSG00000181852 ENSMUSG00000025373 UniProt Q9H4P4 Q8BH75 RefSeq (mRNA) NM_001242826 NM_005785 NM_194358 NM_194359 NM_001164237 NM_026259 RefSeq (protein) NP_001229755 NP_005776 NP_919339 NP_919340 NP_001157709 NP_080535 Location (UCSC) Chr 12: 56.2 – 56.22 Mb Chr 10: 128.25 – 128.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Interactions

RNF41 has been shown to interact with USP8.

See also

• RING finger domain

Further reading

• Cao Z, Wu X, Yen L, Sweeney C, Carraway KL (2007). "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. doi:10.1128/MCB.01245-06. PMC 1820496. PMID 17210635.
• Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.
• Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
• Qiu XB, Markant SL, Yuan J, Goldberg AL (2004). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Qiu XB, Goldberg AL (2002). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. Bibcode:2002PNAS...9914843Q. doi:10.1073/pnas.232580999. PMC 137506. PMID 12411582.
• Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. Bibcode:2002PNAS...99.2866D. doi:10.1073/pnas.052709799. PMC 122439. PMID 11867753.
• Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. doi:10.1006/bcmd.2001.0390. PMID 11358394.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

External links

• RNF41+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• RNF41 human gene location in the UCSC Genome Browser.
• RNF41 human gene details in the UCSC Genome Browser.