ROBO4

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.

ROBO4
Identifiers
Aliases	ROBO4, ECSM4, MRB, roundabout guidance receptor 4, AOVD3
External IDs	OMIM: 607528; MGI: 1921394; HomoloGene: 10397; GeneCards: ROBO4; OMA:ROBO4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.2 Start 124,883,691 bp End 124,898,500 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A4 Start 37,313,193 bp End 37,326,411 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung apex of heart upper lobe of lung upper lobe of left lung spleen sural nerve subcutaneous adipose tissue right lung visceral pleura endothelial cell Top expressed in interventricular septum muscle of thigh left lung right ventricle digastric muscle myocardium of ventricle urethra female urethra left lung lobe extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity cell-cell adhesion mediator activity Cellular component integral component of membrane extracellular exosome plasma membrane axon Biological process multicellular organism development cell differentiation regulation of cell migration angiogenesis homophilic cell adhesion via plasma membrane adhesion molecules axon guidance dendrite self-avoidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54538 74144 Ensembl ENSG00000154133 ENSMUSG00000032125 UniProt Q8WZ75 Q8C310 RefSeq (mRNA) NM_001301088 NM_019055 NM_028783 NM_001309390 RefSeq (protein) NP_001288017 NP_061928 NP_001296319 NP_083059 Location (UCSC) Chr 11: 124.88 – 124.9 Mb Chr 9: 37.31 – 37.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Schmucker D (September 2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron. 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427. S2CID 15871522.
• Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R (April 2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics. 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987.
• Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
• Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R (May 2005). "roundabout4 is essential for angiogenesis in vivo". Proceedings of the National Academy of Sciences of the United States of America. 102 (18): 6373–8. Bibcode:2005PNAS..102.6373B. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270.
• Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP (July 2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochemical and Biophysical Research Communications. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S (June 2006). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncology Reports. 15 (6): 1437–43. doi:10.3892/or.15.6.1437. PMID 16685377.
• Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC (June 2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circulation Research. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.