Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.[5][6]

RRAGC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRAGC, GTR2, RAGC, TIB929, Ras related GTP binding C
External IDsOMIM: 608267; MGI: 1858751; HomoloGene: 39141; GeneCards: RRAGC; OMA:RRAGC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022157
NM_001271851

NM_017475

RefSeq (protein)

NP_001258780
NP_071440

NP_059503

Location (UCSC)Chr 1: 38.84 – 38.86 MbChr 4: 123.81 – 123.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[5]

Interactions

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RRAGC has been shown to interact with RRAGA.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116954Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028646Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RRAGC Ras-related GTP binding C".
  6. ^ a b Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

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