RTFDC1

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene.

RTF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZE, 2DB9, 3U1U, 4L1P, 4L1U
Identifiers
Aliases	15890 RTF1, RTF2, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component, RTF2, C20orf43, CDAO5, HSPC164, SHUJUN-3, replication termination factor 2 domain containing 1, replication termination factor 2, RTFDC1
External IDs	OMIM: 611633; MGI: 1309480; HomoloGene: 133868 9501; GeneCards: RTF2 RTF1, RTF2; OMA:RTF1, RTF2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1, 20q13.31 Start 41,408,408 bp End 41,483,563 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 119,675,068 bp End 119,735,407 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Skeletal muscle tissue of rectus abdominis palpebral conjunctiva epithelium of colon ventricular zone bone marrow cells cerebellar hemisphere Skeletal muscle tissue of biceps brachii body of tongue monocyte Top expressed in tail of embryo zygote genital tubercle hand yolk sac superior cervical ganglion foot interventricular septum primitive streak fossa More reference expression data BioGPS 51507/ More reference expression data
Gene ontology Molecular function protein binding single-stranded DNA binding DNA binding RNA polymerase II C-terminal domain phosphoserine binding RNA binding molecular function Cellular component nucleolus nucleus Cdc73/Paf1 complex nucleoplasm cellular component replication fork chromosome Biological process blastocyst growth histone modification regulation of transcription, DNA-templated positive regulation of transcription elongation from RNA polymerase II promoter histone H3-K4 trimethylation positive regulation of histone H3-K4 methylation transcription, DNA-templated Wnt signaling pathway positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II stem cell population maintenance endodermal cell fate commitment transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination mitotic DNA replication termination site-specific DNA replication termination at RTS1 barrier biological process cellular response to hydroxyurea regulation of DNA stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23168,51507 23168,51507 76246 Ensembl ENSG00000137815 ENSG00000022277 ENSMUSG00000027304 UniProt Q92541 Q9BY42 A2AQ19 RefSeq (mRNA) NM_015138 NM_001283035 NM_001283036 NM_001283037 NM_016407 NM_030112 RefSeq (protein) NP_055953 NP_001269964 NP_001269965 NP_001269966 NP_057491 NP_084388 Location (UCSC) Chr 15: 41.41 – 41.48 Mb Chr 2: 119.68 – 119.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human RTFDC1 genome location and RTFDC1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.